※ PP2C family introduction

    Metal-dependent protein phosphatases (PPM) include protein phosphatases which dependent on manganese/magnesium ions (Mn²⁺/Mg²⁺). PPM group contains a high conserved catalytic domain instead of catalytic subunit and different regulatory domains determining the substrate recognition and function diversity. Like PPP group, metal ions play an important role in dephosphorylation reaction (1). PP2C contains 19 members in human genome, including PP2C like phosphatases. What's more, PP2C is one of the largest type of protein phosphatases in plants with at least 76 members in Arabidopsis thaliana. PP2C family members are involved in varieties of cellular processes including cell cycle, splicing, cellular stress signaling and some members function as tumor suppressor (2).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837
2. Lammers, T. and Lavi, S. (2007) Role of type 2C protein phosphatases in growth regulation and in cellular stress signaling. Crit Rev Biochem Mol Biol, 42, 437-461. PMID: 18066953

  Reviewed (0)  or Unreviewed (6) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Ast-0182	CADATEAG00008985	Q0D1V2	ATEG_00082
2		iEKPD-Ast-0183	CADATEAG00009339	Q0CNA7	ATEG_04827
3		iEKPD-Ast-0172	CADATEAG00005233	Q0CM70	ATEG_05214
4		iEKPD-Ast-0158	CADATEAG00000625	Q0CKI5	ATEG_05799
5		iEKPD-Ast-0161	CADATEAG00001470	Q0CJG1	ATEG_06173
6		iEKPD-Ast-0186	CADATEAG00009944	Q0CCN0	ATEG_08554