※ PP2C family introduction

    Metal-dependent protein phosphatases (PPM) include protein phosphatases which dependent on manganese/magnesium ions (Mn²⁺/Mg²⁺). PPM group contains a high conserved catalytic domain instead of catalytic subunit and different regulatory domains determining the substrate recognition and function diversity. Like PPP group, metal ions play an important role in dephosphorylation reaction (1). PP2C contains 19 members in human genome, including PP2C like phosphatases. What's more, PP2C is one of the largest type of protein phosphatases in plants with at least 76 members in Arabidopsis thaliana. PP2C family members are involved in varieties of cellular processes including cell cycle, splicing, cellular stress signaling and some members function as tumor suppressor (2).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837
2. Lammers, T. and Lavi, S. (2007) Role of type 2C protein phosphatases in growth regulation and in cellular stress signaling. Crit Rev Biochem Mol Biol, 42, 437-461. PMID: 18066953

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Blg-0129	BGHDH14_bgh00423	N1J687	BGHDH14_bgh00423
2		iEKPD-Blg-0133	BGHDH14_bgh01960	N1JPB3	BGHDH14_bgh01960
3		iEKPD-Blg-0135	BGHDH14_bgh03529	N1JIW2	BGHDH14_bgh03529
4		iEKPD-Blg-0146	BGHDH14_bgh05516	N1JER5	BGHDH14_bgh05516
5		iEKPD-Blg-0151	BGHDH14_bghG004099000001001	N1JJ77	BGHDH14_bghG004099000001001