※ PP2C family introduction

    Metal-dependent protein phosphatases (PPM) include protein phosphatases which dependent on manganese/magnesium ions (Mn²⁺/Mg²⁺). PPM group contains a high conserved catalytic domain instead of catalytic subunit and different regulatory domains determining the substrate recognition and function diversity. Like PPP group, metal ions play an important role in dephosphorylation reaction (1). PP2C contains 19 members in human genome, including PP2C like phosphatases. What's more, PP2C is one of the largest type of protein phosphatases in plants with at least 76 members in Arabidopsis thaliana. PP2C family members are involved in varieties of cellular processes including cell cycle, splicing, cellular stress signaling and some members function as tumor suppressor (2).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837
2. Lammers, T. and Lavi, S. (2007) Role of type 2C protein phosphatases in growth regulation and in cellular stress signaling. Crit Rev Biochem Mol Biol, 42, 437-461. PMID: 18066953

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Cii-0335	ENSCING00000002414.3	F6QHU2
2		iEKPD-Cii-0329	ENSCING00000012896.2	F6PTJ9
3		iEKPD-Cii-0294	ENSCING00000020770.1	H2Y3J2
4		iEKPD-Cii-0337	ENSCING00000024121.1	H2XNS7
5		iEKPD-Cii-0328	ENSCING00000004389.3	F7AUM2	LOC100178049
6		iEKPD-Cii-0343	ENSCING00000003713.3	F7BEV9	LOC100179989
7		iEKPD-Cii-0330	ENSCING00000007973.3	F6WRK0	LOC100181266
8		iEKPD-Cii-0334	ENSCING00000008148.3	F6VFZ2	LOC100183363
9		iEKPD-Cii-0346	ENSCING00000007208.3	F6Y7N9	LOC100183669