※ PP2C family introduction

    Metal-dependent protein phosphatases (PPM) include protein phosphatases which dependent on manganese/magnesium ions (Mn²⁺/Mg²⁺). PPM group contains a high conserved catalytic domain instead of catalytic subunit and different regulatory domains determining the substrate recognition and function diversity. Like PPP group, metal ions play an important role in dephosphorylation reaction (1). PP2C contains 19 members in human genome, including PP2C like phosphatases. What's more, PP2C is one of the largest type of protein phosphatases in plants with at least 76 members in Arabidopsis thaliana. PP2C family members are involved in varieties of cellular processes including cell cycle, splicing, cellular stress signaling and some members function as tumor suppressor (2).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837
2. Lammers, T. and Lavi, S. (2007) Role of type 2C protein phosphatases in growth regulation and in cellular stress signaling. Crit Rev Biochem Mol Biol, 42, 437-461. PMID: 18066953

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Coo-0142	Cob_01595	N4UMH0	Cob_01595
2		iEKPD-Coo-0146	Cob_03321	N4VWQ8	Cob_03321
3		iEKPD-Coo-0147	Cob_03467	N4VX85	Cob_03467
4		iEKPD-Coo-0150	Cob_04072	N4VZP4	Cob_04072
5		iEKPD-Coo-0155	Cob_05364	N4VGZ5	Cob_05364
6		iEKPD-Coo-0157	Cob_05880	N4VTY3	Cob_05880
7		iEKPD-Coo-0163	Cob_09565	N4V3F2	Cob_09565