※ PP2C family introduction

    Metal-dependent protein phosphatases (PPM) include protein phosphatases which dependent on manganese/magnesium ions (Mn²⁺/Mg²⁺). PPM group contains a high conserved catalytic domain instead of catalytic subunit and different regulatory domains determining the substrate recognition and function diversity. Like PPP group, metal ions play an important role in dephosphorylation reaction (1). PP2C contains 19 members in human genome, including PP2C like phosphatases. What's more, PP2C is one of the largest type of protein phosphatases in plants with at least 76 members in Arabidopsis thaliana. PP2C family members are involved in varieties of cellular processes including cell cycle, splicing, cellular stress signaling and some members function as tumor suppressor (2).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837
2. Lammers, T. and Lavi, S. (2007) Role of type 2C protein phosphatases in growth regulation and in cellular stress signaling. Crit Rev Biochem Mol Biol, 42, 437-461. PMID: 18066953

  Reviewed (0)  or Unreviewed (6) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Crn-0114	CNA04830	Q5KNY9	CNA04830
2		iEKPD-Crn-0120	CNC00360	Q5KL88	CNC00360
3		iEKPD-Crn-0131	CNG00560	Q5KEG9	CNG00560
4		iEKPD-Crn-0272	CNG03670	Q5KDK1	CNG03670
5		iEKPD-Crn-0134	CNH03270	Q5KD47	CNH03270
6		iEKPD-Crn-0140	CNN01430	Q5K719	CNN01430