※ PP2C family introduction

    Metal-dependent protein phosphatases (PPM) include protein phosphatases which dependent on manganese/magnesium ions (Mn²⁺/Mg²⁺). PPM group contains a high conserved catalytic domain instead of catalytic subunit and different regulatory domains determining the substrate recognition and function diversity. Like PPP group, metal ions play an important role in dephosphorylation reaction (1). PP2C contains 19 members in human genome, including PP2C like phosphatases. What's more, PP2C is one of the largest type of protein phosphatases in plants with at least 76 members in Arabidopsis thaliana. PP2C family members are involved in varieties of cellular processes including cell cycle, splicing, cellular stress signaling and some members function as tumor suppressor (2).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837
2. Lammers, T. and Lavi, S. (2007) Role of type 2C protein phosphatases in growth regulation and in cellular stress signaling. Crit Rev Biochem Mol Biol, 42, 437-461. PMID: 18066953

  Reviewed (0)  or Unreviewed (6) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Cym-0093	CME177C	M1V717	CYME_CME177C
2		iEKPD-Cym-0187	CMG113C	M1VBE7	CYME_CMG113C
3		iEKPD-Cym-0096	CMG203C	M1VGB8	CYME_CMG203C
4		iEKPD-Cym-0101	CMH032C	M1V4X5	CYME_CMH032C
5		iEKPD-Cym-0084	CMK117C	M1V8B7	CYME_CMK117C
6		iEKPD-Cym-0085	CMS179C	M1UWW3	CYME_CMS179C