※ PP2C family introduction

    Metal-dependent protein phosphatases (PPM) include protein phosphatases which dependent on manganese/magnesium ions (Mn²⁺/Mg²⁺). PPM group contains a high conserved catalytic domain instead of catalytic subunit and different regulatory domains determining the substrate recognition and function diversity. Like PPP group, metal ions play an important role in dephosphorylation reaction (1). PP2C contains 19 members in human genome, including PP2C like phosphatases. What's more, PP2C is one of the largest type of protein phosphatases in plants with at least 76 members in Arabidopsis thaliana. PP2C family members are involved in varieties of cellular processes including cell cycle, splicing, cellular stress signaling and some members function as tumor suppressor (2).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837
2. Lammers, T. and Lavi, S. (2007) Role of type 2C protein phosphatases in growth regulation and in cellular stress signaling. Crit Rev Biochem Mol Biol, 42, 437-461. PMID: 18066953

  Reviewed (0)  or Unreviewed (18) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Dan-0486	ENSDNOG00000000444.3
2		iEKPD-Dan-0500	ENSDNOG00000003987.2
3		iEKPD-Dan-0503	ENSDNOG00000004707.3
4		iEKPD-Dan-0504	ENSDNOG00000005119.3
5		iEKPD-Dan-0513	ENSDNOG00000009468.2
6		iEKPD-Dan-0537	ENSDNOG00000014098.3
7		iEKPD-Dan-0541	ENSDNOG00000015155.3
8		iEKPD-Dan-0548	ENSDNOG00000017804.3
9		iEKPD-Dan-0549	ENSDNOG00000017928.3
10		iEKPD-Dan-0562	ENSDNOG00000025911.2
11		iEKPD-Dan-0574	ENSDNOG00000033686.1
12		iEKPD-Dan-0580	ENSDNOG00000035382.1
13		iEKPD-Dan-0583	ENSDNOG00000036361.1
14		iEKPD-Dan-0587	ENSDNOG00000036965.1
15		iEKPD-Dan-0607	ENSDNOG00000043407.1
16		iEKPD-Dan-0620	ENSDNOG00000045771.1
17		iEKPD-Dan-0623	ENSDNOG00000046608.1
18		iEKPD-Dan-0632	ENSDNOG00000049056.1