※ PP2C family introduction

    Metal-dependent protein phosphatases (PPM) include protein phosphatases which dependent on manganese/magnesium ions (Mn²⁺/Mg²⁺). PPM group contains a high conserved catalytic domain instead of catalytic subunit and different regulatory domains determining the substrate recognition and function diversity. Like PPP group, metal ions play an important role in dephosphorylation reaction (1). PP2C contains 19 members in human genome, including PP2C like phosphatases. What's more, PP2C is one of the largest type of protein phosphatases in plants with at least 76 members in Arabidopsis thaliana. PP2C family members are involved in varieties of cellular processes including cell cycle, splicing, cellular stress signaling and some members function as tumor suppressor (2).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837
2. Lammers, T. and Lavi, S. (2007) Role of type 2C protein phosphatases in growth regulation and in cellular stress signaling. Crit Rev Biochem Mol Biol, 42, 437-461. PMID: 18066953

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Dos-0158	DOTSEDRAFT_73353	N1PJA3	cyr1
2		iEKPD-Dos-0136	DOTSEDRAFT_122989	N1PVB4	DOTSEDRAFT_122989
3		iEKPD-Dos-0138	DOTSEDRAFT_125535	N1PTL4	DOTSEDRAFT_125535
4		iEKPD-Dos-0143	DOTSEDRAFT_23988	N1PN97	DOTSEDRAFT_23988
5		iEKPD-Dos-0145	DOTSEDRAFT_44824	N1PQH9	DOTSEDRAFT_44824
6		iEKPD-Dos-0146	DOTSEDRAFT_50057	N1Q3S9	DOTSEDRAFT_50057
7		iEKPD-Dos-0155	DOTSEDRAFT_71567	N1PJT8	DOTSEDRAFT_71567
8		iEKPD-Dos-0168	DOTSEDRAFT_87976	N1PQN1	DOTSEDRAFT_87976