※ PP2C family introduction

    Metal-dependent protein phosphatases (PPM) include protein phosphatases which dependent on manganese/magnesium ions (Mn²⁺/Mg²⁺). PPM group contains a high conserved catalytic domain instead of catalytic subunit and different regulatory domains determining the substrate recognition and function diversity. Like PPP group, metal ions play an important role in dephosphorylation reaction (1). PP2C contains 19 members in human genome, including PP2C like phosphatases. What's more, PP2C is one of the largest type of protein phosphatases in plants with at least 76 members in Arabidopsis thaliana. PP2C family members are involved in varieties of cellular processes including cell cycle, splicing, cellular stress signaling and some members function as tumor suppressor (2).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837
2. Lammers, T. and Lavi, S. (2007) Role of type 2C protein phosphatases in growth regulation and in cellular stress signaling. Crit Rev Biochem Mol Biol, 42, 437-461. PMID: 18066953

  Reviewed (0)  or Unreviewed (6) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Fuo-0195	FOXG_00154	A0A0D2X8E5
2		iEKPD-Fuo-0198	FOXG_00617	A0A0D2X9Q2	FOXG_00617
3		iEKPD-Fuo-0209	FOXG_05154	A0A0D2XMH7	FOXG_05154
4		iEKPD-Fuo-0214	FOXG_07912	A0A0D2XVA4	FOXG_07912
5		iEKPD-Fuo-0222	FOXG_09277	A0A0D2XZ55	FOXG_09277
6		iEKPD-Fuo-0229	FOXG_11525	A0A0D2Y5H0	FOXG_11525