※ PP2C family introduction

    Metal-dependent protein phosphatases (PPM) include protein phosphatases which dependent on manganese/magnesium ions (Mn²⁺/Mg²⁺). PPM group contains a high conserved catalytic domain instead of catalytic subunit and different regulatory domains determining the substrate recognition and function diversity. Like PPP group, metal ions play an important role in dephosphorylation reaction (1). PP2C contains 19 members in human genome, including PP2C like phosphatases. What's more, PP2C is one of the largest type of protein phosphatases in plants with at least 76 members in Arabidopsis thaliana. PP2C family members are involved in varieties of cellular processes including cell cycle, splicing, cellular stress signaling and some members function as tumor suppressor (2).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837
2. Lammers, T. and Lavi, S. (2007) Role of type 2C protein phosphatases in growth regulation and in cellular stress signaling. Crit Rev Biochem Mol Biol, 42, 437-461. PMID: 18066953

  Reviewed (0)  or Unreviewed (7) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Fup-0145	FPSE_00131	K3VUT1	FPSE_00131
2		iEKPD-Fup-0154	FPSE_02050	K3UYH4	FPSE_02050
3		iEKPD-Fup-0158	FPSE_03633	K3VQI7	FPSE_03633
4		iEKPD-Fup-0168	FPSE_06202	K3VHC2	FPSE_06202
5		iEKPD-Fup-0169	FPSE_06561	K3UMF5	FPSE_06561
6		iEKPD-Fup-0172	FPSE_07288	K3UKR5	FPSE_07288
7		iEKPD-Fup-0153	FPSE_01775	K3VR01	MAC1