※ PP2C family introduction

    Metal-dependent protein phosphatases (PPM) include protein phosphatases which dependent on manganese/magnesium ions (Mn²⁺/Mg²⁺). PPM group contains a high conserved catalytic domain instead of catalytic subunit and different regulatory domains determining the substrate recognition and function diversity. Like PPP group, metal ions play an important role in dephosphorylation reaction (1). PP2C contains 19 members in human genome, including PP2C like phosphatases. What's more, PP2C is one of the largest type of protein phosphatases in plants with at least 76 members in Arabidopsis thaliana. PP2C family members are involved in varieties of cellular processes including cell cycle, splicing, cellular stress signaling and some members function as tumor suppressor (2).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837
2. Lammers, T. and Lavi, S. (2007) Role of type 2C protein phosphatases in growth regulation and in cellular stress signaling. Crit Rev Biochem Mol Biol, 42, 437-461. PMID: 18066953

  Reviewed (0)  or Unreviewed (7) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Mao-0140	MGG_00166	G4NE46	MGG_00166
2		iEKPD-Mao-0142	MGG_01351	G4MZ06	MGG_01351
3		iEKPD-Mao-0147	MGG_03154	G4NAS8	MGG_03154
4		iEKPD-Mao-0150	MGG_03918	G4NH71	MGG_03918
5		iEKPD-Mao-0155	MGG_05207	G4N534	MGG_05207
6		iEKPD-Mao-0308	MGG_09898	G4MR48	MGG_09898
7		iEKPD-Mao-0168	MGG_14747	G4MTT9	MGG_14747