※ PP2C family introduction

    Metal-dependent protein phosphatases (PPM) include protein phosphatases which dependent on manganese/magnesium ions (Mn²⁺/Mg²⁺). PPM group contains a high conserved catalytic domain instead of catalytic subunit and different regulatory domains determining the substrate recognition and function diversity. Like PPP group, metal ions play an important role in dephosphorylation reaction (1). PP2C contains 19 members in human genome, including PP2C like phosphatases. What's more, PP2C is one of the largest type of protein phosphatases in plants with at least 76 members in Arabidopsis thaliana. PP2C family members are involved in varieties of cellular processes including cell cycle, splicing, cellular stress signaling and some members function as tumor suppressor (2).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837
2. Lammers, T. and Lavi, S. (2007) Role of type 2C protein phosphatases in growth regulation and in cellular stress signaling. Crit Rev Biochem Mol Biol, 42, 437-461. PMID: 18066953

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Mel-0188	MELLADRAFT_110044	F4RYG9	MELLADRAFT_110044
2		iEKPD-Mel-0189	MELLADRAFT_115584	F4RBW6	MELLADRAFT_115584
3		iEKPD-Mel-0195	MELLADRAFT_22293	F4RJS7	MELLADRAFT_22293
4		iEKPD-Mel-0200	MELLADRAFT_33437	F4R8P7	MELLADRAFT_33437
5		iEKPD-Mel-0209	MELLADRAFT_46948	F4R9F5	MELLADRAFT_46948
6		iEKPD-Mel-0216	MELLADRAFT_75803	F4S547	MELLADRAFT_75803
7		iEKPD-Mel-0223	MELLADRAFT_95423	F4S992	MELLADRAFT_95423