※ PP2C family introduction

    Metal-dependent protein phosphatases (PPM) include protein phosphatases which dependent on manganese/magnesium ions (Mn²⁺/Mg²⁺). PPM group contains a high conserved catalytic domain instead of catalytic subunit and different regulatory domains determining the substrate recognition and function diversity. Like PPP group, metal ions play an important role in dephosphorylation reaction (1). PP2C contains 19 members in human genome, including PP2C like phosphatases. What's more, PP2C is one of the largest type of protein phosphatases in plants with at least 76 members in Arabidopsis thaliana. PP2C family members are involved in varieties of cellular processes including cell cycle, splicing, cellular stress signaling and some members function as tumor suppressor (2).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837
2. Lammers, T. and Lavi, S. (2007) Role of type 2C protein phosphatases in growth regulation and in cellular stress signaling. Crit Rev Biochem Mol Biol, 42, 437-461. PMID: 18066953

  Reviewed (0)  or Unreviewed (7) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Miv-0136	MVLG_00151	U5GY82	MVLG_00151
2		iEKPD-Miv-0141	MVLG_01348	U5H1V1	MVLG_01348
3		iEKPD-Miv-0145	MVLG_03759	U5H965	MVLG_03759
4		iEKPD-Miv-0147	MVLG_03962	U5H9S3	MVLG_03962
5		iEKPD-Miv-0157	MVLG_05600	U5HER0	MVLG_05600
6		iEKPD-Miv-0162	MVLG_06067	U5HG47	MVLG_06067
7		iEKPD-Miv-0165	MVLG_06685	U5HI17	MVLG_06685