※ PP2C family introduction

    Metal-dependent protein phosphatases (PPM) include protein phosphatases which dependent on manganese/magnesium ions (Mn²⁺/Mg²⁺). PPM group contains a high conserved catalytic domain instead of catalytic subunit and different regulatory domains determining the substrate recognition and function diversity. Like PPP group, metal ions play an important role in dephosphorylation reaction (1). PP2C contains 19 members in human genome, including PP2C like phosphatases. What's more, PP2C is one of the largest type of protein phosphatases in plants with at least 76 members in Arabidopsis thaliana. PP2C family members are involved in varieties of cellular processes including cell cycle, splicing, cellular stress signaling and some members function as tumor suppressor (2).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837
2. Lammers, T. and Lavi, S. (2007) Role of type 2C protein phosphatases in growth regulation and in cellular stress signaling. Crit Rev Biochem Mol Biol, 42, 437-461. PMID: 18066953

  Reviewed (0)  or Unreviewed (17) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Mim-0483	ENSMICG00000000256.3
2		iEKPD-Mim-0486	ENSMICG00000000343.3
3		iEKPD-Mim-0494	ENSMICG00000001559.3
4		iEKPD-Mim-0500	ENSMICG00000001901.3
5		iEKPD-Mim-0506	ENSMICG00000002725.3
6		iEKPD-Mim-0535	ENSMICG00000007351.3
7		iEKPD-Mim-0540	ENSMICG00000008341.3
8		iEKPD-Mim-0551	ENSMICG00000011424.3
9		iEKPD-Mim-0560	ENSMICG00000014711.3
10		iEKPD-Mim-0564	ENSMICG00000015895.3
11		iEKPD-Mim-0589	ENSMICG00000029291.2
12		iEKPD-Mim-0596	ENSMICG00000031392.2
13		iEKPD-Mim-0605	ENSMICG00000035392.2
14		iEKPD-Mim-0610	ENSMICG00000036990.2
15		iEKPD-Mim-0612	ENSMICG00000037298.2
16		iEKPD-Mim-0619	ENSMICG00000042392.1
17		iEKPD-Mim-0626	ENSMICG00000045611.1