※ PP2C family introduction

    Metal-dependent protein phosphatases (PPM) include protein phosphatases which dependent on manganese/magnesium ions (Mn²⁺/Mg²⁺). PPM group contains a high conserved catalytic domain instead of catalytic subunit and different regulatory domains determining the substrate recognition and function diversity. Like PPP group, metal ions play an important role in dephosphorylation reaction (1). PP2C contains 19 members in human genome, including PP2C like phosphatases. What's more, PP2C is one of the largest type of protein phosphatases in plants with at least 76 members in Arabidopsis thaliana. PP2C family members are involved in varieties of cellular processes including cell cycle, splicing, cellular stress signaling and some members function as tumor suppressor (2).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837
2. Lammers, T. and Lavi, S. (2007) Role of type 2C protein phosphatases in growth regulation and in cellular stress signaling. Crit Rev Biochem Mol Biol, 42, 437-461. PMID: 18066953

  Reviewed (0)  or Unreviewed (18) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Ocp-0454	ENSOPRG00000000342.1
2		iEKPD-Ocp-0463	ENSOPRG00000001055.2
3		iEKPD-Ocp-0465	ENSOPRG00000001264.1
4		iEKPD-Ocp-0479	ENSOPRG00000002734.1
5		iEKPD-Ocp-0481	ENSOPRG00000002797.1
6		iEKPD-Ocp-0485	ENSOPRG00000003848.1
7		iEKPD-Ocp-0491	ENSOPRG00000005107.1
8		iEKPD-Ocp-0509	ENSOPRG00000008548.1
9		iEKPD-Ocp-0512	ENSOPRG00000008857.2
10		iEKPD-Ocp-0514	ENSOPRG00000009000.1
11		iEKPD-Ocp-0519	ENSOPRG00000009993.1
12		iEKPD-Ocp-0520	ENSOPRG00000010105.1
13		iEKPD-Ocp-0528	ENSOPRG00000010855.1
14		iEKPD-Ocp-0530	ENSOPRG00000011286.2
15		iEKPD-Ocp-0545	ENSOPRG00000012823.1
16		iEKPD-Ocp-0554	ENSOPRG00000014325.1
17		iEKPD-Ocp-0578	ENSOPRG00000016702.1
18		iEKPD-Ocp-0584	ENSOPRG00000017232.1