※ PP2C family introduction

    Metal-dependent protein phosphatases (PPM) include protein phosphatases which dependent on manganese/magnesium ions (Mn²⁺/Mg²⁺). PPM group contains a high conserved catalytic domain instead of catalytic subunit and different regulatory domains determining the substrate recognition and function diversity. Like PPP group, metal ions play an important role in dephosphorylation reaction (1). PP2C contains 19 members in human genome, including PP2C like phosphatases. What's more, PP2C is one of the largest type of protein phosphatases in plants with at least 76 members in Arabidopsis thaliana. PP2C family members are involved in varieties of cellular processes including cell cycle, splicing, cellular stress signaling and some members function as tumor suppressor (2).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837
2. Lammers, T. and Lavi, S. (2007) Role of type 2C protein phosphatases in growth regulation and in cellular stress signaling. Crit Rev Biochem Mol Biol, 42, 437-461. PMID: 18066953

  Reviewed (0)  or Unreviewed (17) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Ocd-0501	ENSODEG00000001406.1
2		iEKPD-Ocd-0502	ENSODEG00000001605.1
3		iEKPD-Ocd-0544	ENSODEG00000006212.1
4		iEKPD-Ocd-0546	ENSODEG00000006334.1
5		iEKPD-Ocd-0561	ENSODEG00000007627.1
6		iEKPD-Ocd-0570	ENSODEG00000008552.1
7		iEKPD-Ocd-0580	ENSODEG00000009338.1
8		iEKPD-Ocd-0582	ENSODEG00000009636.1
9		iEKPD-Ocd-0588	ENSODEG00000010585.1
10		iEKPD-Ocd-0597	ENSODEG00000012106.1
11		iEKPD-Ocd-0609	ENSODEG00000013279.1
12		iEKPD-Ocd-0610	ENSODEG00000013373.1
13		iEKPD-Ocd-0617	ENSODEG00000013831.1
14		iEKPD-Ocd-0619	ENSODEG00000014074.1
15		iEKPD-Ocd-0634	ENSODEG00000015803.1
16		iEKPD-Ocd-0638	ENSODEG00000016321.1
17		iEKPD-Ocd-0652	ENSODEG00000018248.1