※ PP2C family introduction

    Metal-dependent protein phosphatases (PPM) include protein phosphatases which dependent on manganese/magnesium ions (Mn²⁺/Mg²⁺). PPM group contains a high conserved catalytic domain instead of catalytic subunit and different regulatory domains determining the substrate recognition and function diversity. Like PPP group, metal ions play an important role in dephosphorylation reaction (1). PP2C contains 19 members in human genome, including PP2C like phosphatases. What's more, PP2C is one of the largest type of protein phosphatases in plants with at least 76 members in Arabidopsis thaliana. PP2C family members are involved in varieties of cellular processes including cell cycle, splicing, cellular stress signaling and some members function as tumor suppressor (2).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837
2. Lammers, T. and Lavi, S. (2007) Role of type 2C protein phosphatases in growth regulation and in cellular stress signaling. Crit Rev Biochem Mol Biol, 42, 437-461. PMID: 18066953

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Ora-0585	ENSOANG00000004965.2	F7DJ14
2		iEKPD-Ora-0596	ENSOANG00000004988.2	F7GBD9
3		iEKPD-Ora-0580	ENSOANG00000006156.1	F7BSI6
4		iEKPD-Ora-0582	ENSOANG00000008982.1	F7F2D9
5		iEKPD-Ora-0588	ENSOANG00000014788.1	F7E995
6		iEKPD-Ora-0507	ENSOANG00000022048.2	F7E0J3
7		iEKPD-Ora-0589	ENSOANG00000015598.3	F7DRR3	ILKAP
8		iEKPD-Ora-1182	ENSOANG00000008185.3	F6RG36	PHLPP2
9		iEKPD-Ora-0577	ENSOANG00000011857.3	F6ZZ09	PPM1A
10		iEKPD-Ora-0604	ENSOANG00000011523.2	F6S9G3	PPM1D
11		iEKPD-Ora-0592	ENSOANG00000008495.3	F6XL38	PPM1E
12		iEKPD-Ora-0573	ENSOANG00000013295.3	F6S4D2	PPM1G
13		iEKPD-Ora-0586	ENSOANG00000002615.2	F7E0N5	PPM1J
14		iEKPD-Ora-0581	ENSOANG00000004786.2	F7FN55	PPTC7