※ PP2C family introduction

    Metal-dependent protein phosphatases (PPM) include protein phosphatases which dependent on manganese/magnesium ions (Mn²⁺/Mg²⁺). PPM group contains a high conserved catalytic domain instead of catalytic subunit and different regulatory domains determining the substrate recognition and function diversity. Like PPP group, metal ions play an important role in dephosphorylation reaction (1). PP2C contains 19 members in human genome, including PP2C like phosphatases. What's more, PP2C is one of the largest type of protein phosphatases in plants with at least 76 members in Arabidopsis thaliana. PP2C family members are involved in varieties of cellular processes including cell cycle, splicing, cellular stress signaling and some members function as tumor suppressor (2).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837
2. Lammers, T. and Lavi, S. (2007) Role of type 2C protein phosphatases in growth regulation and in cellular stress signaling. Crit Rev Biochem Mol Biol, 42, 437-461. PMID: 18066953

  Reviewed (0)  or Unreviewed (6) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Put-0133	PTTG_01776	A0A180G0Z3	PTTG_01776
2		iEKPD-Put-0134	PTTG_02220	A0A180GI13	PTTG_02220
3		iEKPD-Put-0136	PTTG_02320	A0A180GAU2	PTTG_02320
4		iEKPD-Put-0276	PTTG_03037	A0A180GQE4	PTTG_03037
5		iEKPD-Put-0144	PTTG_03808	A0A0C4ESM9	PTTG_03808
6		iEKPD-Put-0155	PTTG_07131	A0A180H0H3	PTTG_07131