※ PP2C family introduction

    Metal-dependent protein phosphatases (PPM) include protein phosphatases which dependent on manganese/magnesium ions (Mn²⁺/Mg²⁺). PPM group contains a high conserved catalytic domain instead of catalytic subunit and different regulatory domains determining the substrate recognition and function diversity. Like PPP group, metal ions play an important role in dephosphorylation reaction (1). PP2C contains 19 members in human genome, including PP2C like phosphatases. What's more, PP2C is one of the largest type of protein phosphatases in plants with at least 76 members in Arabidopsis thaliana. PP2C family members are involved in varieties of cellular processes including cell cycle, splicing, cellular stress signaling and some members function as tumor suppressor (2).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837
2. Lammers, T. and Lavi, S. (2007) Role of type 2C protein phosphatases in growth regulation and in cellular stress signaling. Crit Rev Biochem Mol Biol, 42, 437-461. PMID: 18066953

  Reviewed (0)  or Unreviewed (8) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Pys-0142	PTT_06926	E3RGJ1	PTT_06926
2		iEKPD-Pys-0147	PTT_10182	E3RNM7	PTT_10182
3		iEKPD-Pys-0149	PTT_10762	E3RQ04	PTT_10762
4		iEKPD-Pys-0154	PTT_11755	E3RSA2	PTT_11755
5		iEKPD-Pys-0159	PTT_12766	E3RUJ6	PTT_12766
6		iEKPD-Pys-0163	PTT_15332	E3RZZ7	PTT_15332
7		iEKPD-Pys-0166	PTT_15565	E3S0I8	PTT_15565
8		iEKPD-Pys-0175	PTT_19723	E3S9J2	PTT_19723