※ PP2C family introduction

    Metal-dependent protein phosphatases (PPM) include protein phosphatases which dependent on manganese/magnesium ions (Mn²⁺/Mg²⁺). PPM group contains a high conserved catalytic domain instead of catalytic subunit and different regulatory domains determining the substrate recognition and function diversity. Like PPP group, metal ions play an important role in dephosphorylation reaction (1). PP2C contains 19 members in human genome, including PP2C like phosphatases. What's more, PP2C is one of the largest type of protein phosphatases in plants with at least 76 members in Arabidopsis thaliana. PP2C family members are involved in varieties of cellular processes including cell cycle, splicing, cellular stress signaling and some members function as tumor suppressor (2).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837
2. Lammers, T. and Lavi, S. (2007) Role of type 2C protein phosphatases in growth regulation and in cellular stress signaling. Crit Rev Biochem Mol Biol, 42, 437-461. PMID: 18066953

  Reviewed (0)  or Unreviewed (6) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Scc-0136	SPOG_01719	S9VXT8	SPOG_01719
2		iEKPD-Scc-0140	SPOG_02393	S9X280	SPOG_02393
3		iEKPD-Scc-0142	SPOG_02738	S9XCI4	SPOG_02738
4		iEKPD-Scc-0145	SPOG_02932	S9X9M3	SPOG_02932
5		iEKPD-Scc-0151	SPOG_03952	S9W1X9	SPOG_03952
6		iEKPD-Scc-0156	SPOG_04792	S9W273	SPOG_04792