※ PP2C family introduction

    Metal-dependent protein phosphatases (PPM) include protein phosphatases which dependent on manganese/magnesium ions (Mn²⁺/Mg²⁺). PPM group contains a high conserved catalytic domain instead of catalytic subunit and different regulatory domains determining the substrate recognition and function diversity. Like PPP group, metal ions play an important role in dephosphorylation reaction (1). PP2C contains 19 members in human genome, including PP2C like phosphatases. What's more, PP2C is one of the largest type of protein phosphatases in plants with at least 76 members in Arabidopsis thaliana. PP2C family members are involved in varieties of cellular processes including cell cycle, splicing, cellular stress signaling and some members function as tumor suppressor (2).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837
2. Lammers, T. and Lavi, S. (2007) Role of type 2C protein phosphatases in growth regulation and in cellular stress signaling. Crit Rev Biochem Mol Biol, 42, 437-461. PMID: 18066953

  Reviewed (0)  or Unreviewed (6) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Scj-0299	SJAG_01254	B6K065	SJAG_01254
2		iEKPD-Scj-0135	SJAG_01672	B6JYL1	SJAG_01672
3		iEKPD-Scj-0142	SJAG_02433	B6K2G4	SJAG_02433
4		iEKPD-Scj-0149	SJAG_03185	B6K3J8	SJAG_03185
5		iEKPD-Scj-0153	SJAG_03482	B6K4C6	SJAG_03482
6		iEKPD-Scj-0156	SJAG_03893	B6K5C3	SJAG_03893