※ PP2C family introduction

    Metal-dependent protein phosphatases (PPM) include protein phosphatases which dependent on manganese/magnesium ions (Mn²⁺/Mg²⁺). PPM group contains a high conserved catalytic domain instead of catalytic subunit and different regulatory domains determining the substrate recognition and function diversity. Like PPP group, metal ions play an important role in dephosphorylation reaction (1). PP2C contains 19 members in human genome, including PP2C like phosphatases. What's more, PP2C is one of the largest type of protein phosphatases in plants with at least 76 members in Arabidopsis thaliana. PP2C family members are involved in varieties of cellular processes including cell cycle, splicing, cellular stress signaling and some members function as tumor suppressor (2).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837
2. Lammers, T. and Lavi, S. (2007) Role of type 2C protein phosphatases in growth regulation and in cellular stress signaling. Crit Rev Biochem Mol Biol, 42, 437-461. PMID: 18066953

  Reviewed (0)  or Unreviewed (6) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sco-0128	SOCG_00778	S9R3T0	SOCG_00778
2		iEKPD-Sco-0140	SOCG_02060	S9Q3C5	SOCG_02060
3		iEKPD-Sco-0146	SOCG_02793	S9Q1I1	SOCG_02793
4		iEKPD-Sco-0148	SOCG_03133	S9R6J0	SOCG_03133
5		iEKPD-Sco-0149	SOCG_03318	S9RJG2	SOCG_03318
6		iEKPD-Sco-0154	SOCG_04000	S9PX82	SOCG_04000