※ PP2C family introduction

    Metal-dependent protein phosphatases (PPM) include protein phosphatases which dependent on manganese/magnesium ions (Mn²⁺/Mg²⁺). PPM group contains a high conserved catalytic domain instead of catalytic subunit and different regulatory domains determining the substrate recognition and function diversity. Like PPP group, metal ions play an important role in dephosphorylation reaction (1). PP2C contains 19 members in human genome, including PP2C like phosphatases. What's more, PP2C is one of the largest type of protein phosphatases in plants with at least 76 members in Arabidopsis thaliana. PP2C family members are involved in varieties of cellular processes including cell cycle, splicing, cellular stress signaling and some members function as tumor suppressor (2).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837
2. Lammers, T. and Lavi, S. (2007) Role of type 2C protein phosphatases in growth regulation and in cellular stress signaling. Crit Rev Biochem Mol Biol, 42, 437-461. PMID: 18066953

  Reviewed (0)  or Unreviewed (95) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sem-1400	SELMODRAFT_79882
2		iEKPD-Sem-1328	SELMODRAFT_174627	D8RVC6	ABI1A-1
3		iEKPD-Sem-1326	SELMODRAFT_451367	D8S226	ABI1A-2
4		iEKPD-Sem-1332	SELMODRAFT_179532	D8SGL6	ABI1B-2
5		iEKPD-Sem-1319	SELMODRAFT_150390	D8RVS8	ABI1C-1
6		iEKPD-Sem-1402	SELMODRAFT_101879	D8RU84	SELMODRAFT_101879
7		iEKPD-Sem-1331	SELMODRAFT_102683	D8RVC2	SELMODRAFT_102683
8		iEKPD-Sem-1338	SELMODRAFT_103294	D8RWF8	SELMODRAFT_103294
9		iEKPD-Sem-1337	SELMODRAFT_104113	D8RXZ8	SELMODRAFT_104113
10		iEKPD-Sem-1404	SELMODRAFT_109752	D8S6C6	SELMODRAFT_109752
11		iEKPD-Sem-1384	SELMODRAFT_111055	D8S8B6	SELMODRAFT_111055
12		iEKPD-Sem-1315	SELMODRAFT_113714	D8SCD8	SELMODRAFT_113714
13		iEKPD-Sem-1322	SELMODRAFT_115724	D8SFH8	SELMODRAFT_115724
14		iEKPD-Sem-1401	SELMODRAFT_119268	D8SL09	SELMODRAFT_119268
15		iEKPD-Sem-1344	SELMODRAFT_122314	D8SPW3	SELMODRAFT_122314
16		iEKPD-Sem-1366	SELMODRAFT_128825	D8SZR3	SELMODRAFT_128825
17		iEKPD-Sem-1368	SELMODRAFT_137577	D8TDV4	SELMODRAFT_137577
18		iEKPD-Sem-1348	SELMODRAFT_137590	D8TDV9	SELMODRAFT_137590
19		iEKPD-Sem-1321	SELMODRAFT_13828	D8SWL4	SELMODRAFT_13828
20		iEKPD-Sem-1318	SELMODRAFT_13829	D8SW35	SELMODRAFT_13829
21		iEKPD-Sem-1364	SELMODRAFT_14326	D8R5Y0	SELMODRAFT_14326
22		iEKPD-Sem-1317	SELMODRAFT_146683	D8RFG6	SELMODRAFT_146683
23		iEKPD-Sem-1387	SELMODRAFT_153020	D8S699	SELMODRAFT_153020
24		iEKPD-Sem-1341	SELMODRAFT_15402	D8RMK7	SELMODRAFT_15402
25		iEKPD-Sem-1343	SELMODRAFT_15403	D8SLN9	SELMODRAFT_15403
26		iEKPD-Sem-1386	SELMODRAFT_156902	D8SNE0	SELMODRAFT_156902
27		iEKPD-Sem-1389	SELMODRAFT_16052	D8STX7	SELMODRAFT_16052
28		iEKPD-Sem-1383	SELMODRAFT_16054	D8RE55	SELMODRAFT_16054
29		iEKPD-Sem-1390	SELMODRAFT_16807	D8SX05	SELMODRAFT_16807
30		iEKPD-Sem-1335	SELMODRAFT_176266	D8S222	SELMODRAFT_176266
31		iEKPD-Sem-1372	SELMODRAFT_176429	D8S2X3	SELMODRAFT_176429
32		iEKPD-Sem-1901	SELMODRAFT_176991	D8S586	SELMODRAFT_176991
33		iEKPD-Sem-1320	SELMODRAFT_178013	D8S9E5	SELMODRAFT_178013
34		iEKPD-Sem-1336	SELMODRAFT_179889	D8SI12	SELMODRAFT_179889
35		iEKPD-Sem-1399	SELMODRAFT_182066	D8SRG1	SELMODRAFT_182066
36		iEKPD-Sem-1363	SELMODRAFT_183083	D8SVF4	SELMODRAFT_183083
37		iEKPD-Sem-1396	SELMODRAFT_183192	D8SVX2	SELMODRAFT_183192
38		iEKPD-Sem-1377	SELMODRAFT_183449	D8SX07	SELMODRAFT_183449
39		iEKPD-Sem-1385	SELMODRAFT_185274	D8T4C4	SELMODRAFT_185274
40		iEKPD-Sem-1407	SELMODRAFT_187001	D8TB29	SELMODRAFT_187001
41		iEKPD-Sem-1339	SELMODRAFT_227813	D8RBN1	SELMODRAFT_227813
42		iEKPD-Sem-1340	SELMODRAFT_230326	D8QZF1	SELMODRAFT_230326
43		iEKPD-Sem-1327	SELMODRAFT_230443	D8R0R3	SELMODRAFT_230443
44		iEKPD-Sem-1351	SELMODRAFT_233392	D8S8I8	SELMODRAFT_233392
45		iEKPD-Sem-1395	SELMODRAFT_235030	D8ST04	SELMODRAFT_235030
46		iEKPD-Sem-1406	SELMODRAFT_235036	D8ST31	SELMODRAFT_235036
47		iEKPD-Sem-1347	SELMODRAFT_25501	D8TCB7	SELMODRAFT_25501
48		iEKPD-Sem-1358	SELMODRAFT_25706	D8T0N9	SELMODRAFT_25706
49		iEKPD-Sem-1361	SELMODRAFT_25707	D8SVH1	SELMODRAFT_25707
50		iEKPD-Sem-1379	SELMODRAFT_26350	D8T783	SELMODRAFT_26350
51		iEKPD-Sem-1334	SELMODRAFT_270517	D8R3C6	SELMODRAFT_270517
52		iEKPD-Sem-1355	SELMODRAFT_271790	D8SQA0	SELMODRAFT_271790
53		iEKPD-Sem-1403	SELMODRAFT_33326	D8QP48	SELMODRAFT_33326
54		iEKPD-Sem-1381	SELMODRAFT_3338	D8TCQ5	SELMODRAFT_3338
55		iEKPD-Sem-1370	SELMODRAFT_34724	D8QTP8	SELMODRAFT_34724
56		iEKPD-Sem-1345	SELMODRAFT_34798	D8RMJ2	SELMODRAFT_34798
57		iEKPD-Sem-1359	SELMODRAFT_36103	D8S606	SELMODRAFT_36103
58		iEKPD-Sem-1357	SELMODRAFT_36119	D8RP33	SELMODRAFT_36119
59		iEKPD-Sem-1373	SELMODRAFT_36149	D8QPG9	SELMODRAFT_36149
60		iEKPD-Sem-1349	SELMODRAFT_36195	D8RNF1	SELMODRAFT_36195
61		iEKPD-Sem-1353	SELMODRAFT_36694	D8RML4	SELMODRAFT_36694
62		iEKPD-Sem-1375	SELMODRAFT_3798	D8QT88	SELMODRAFT_3798
63		iEKPD-Sem-1376	SELMODRAFT_3800	D8R2H0	SELMODRAFT_3800
64		iEKPD-Sem-1382	SELMODRAFT_38044	D8SU39	SELMODRAFT_38044
65		iEKPD-Sem-1360	SELMODRAFT_4016	D8SLP8	SELMODRAFT_4016
66		iEKPD-Sem-1179	SELMODRAFT_403288	D8QTP1	SELMODRAFT_403288
67		iEKPD-Sem-1350	SELMODRAFT_404287	D8QUV4	SELMODRAFT_404287
68		iEKPD-Sem-1356	SELMODRAFT_405953	D8R069	SELMODRAFT_405953
69		iEKPD-Sem-1180	SELMODRAFT_407327	D8R4P0	SELMODRAFT_407327
70		iEKPD-Sem-1393	SELMODRAFT_409560	D8RBU8	SELMODRAFT_409560
71		iEKPD-Sem-1428	SELMODRAFT_412874	D8RML5	SELMODRAFT_412874
72		iEKPD-Sem-1365	SELMODRAFT_415193	D8RVB7	SELMODRAFT_415193
73		iEKPD-Sem-1388	SELMODRAFT_416013	D8RXT2	SELMODRAFT_416013
74		iEKPD-Sem-1431	SELMODRAFT_421714	D8SG52	SELMODRAFT_421714
75		iEKPD-Sem-1354	SELMODRAFT_425894	D8SUN2	SELMODRAFT_425894
76		iEKPD-Sem-1380	SELMODRAFT_426586	D8SWV1	SELMODRAFT_426586
77		iEKPD-Sem-1397	SELMODRAFT_427596	D8T042	SELMODRAFT_427596
78		iEKPD-Sem-1367	SELMODRAFT_427794	D8T0Q6	SELMODRAFT_427794
79		iEKPD-Sem-1391	SELMODRAFT_428741	D8T3U5	SELMODRAFT_428741
80		iEKPD-Sem-1182	SELMODRAFT_428882	D8T4B0	SELMODRAFT_428882
81		iEKPD-Sem-1908	SELMODRAFT_441116	D8RGN2	SELMODRAFT_441116
82		iEKPD-Sem-1352	SELMODRAFT_46268	D8SLM6	SELMODRAFT_46268
83		iEKPD-Sem-1369	SELMODRAFT_4673	D8QZR5	SELMODRAFT_4673
84		iEKPD-Sem-1378	SELMODRAFT_47683	D8T3T6	SELMODRAFT_47683
85		iEKPD-Sem-1371	SELMODRAFT_5419	D8T8V7	SELMODRAFT_5419
86		iEKPD-Sem-1329	SELMODRAFT_54708	D8S2I5	SELMODRAFT_54708
87		iEKPD-Sem-1374	SELMODRAFT_56326	D8S218	SELMODRAFT_56326
88		iEKPD-Sem-1405	SELMODRAFT_57169	D8S3P4	SELMODRAFT_57169
89		iEKPD-Sem-1333	SELMODRAFT_65249	D8QUC3	SELMODRAFT_65249
90		iEKPD-Sem-1394	SELMODRAFT_6612	D8SLQ0	SELMODRAFT_6612
91		iEKPD-Sem-1398	SELMODRAFT_85661	D8R5B0	SELMODRAFT_85661
92		iEKPD-Sem-1325	SELMODRAFT_85781	D8R5H9	SELMODRAFT_85781
93		iEKPD-Sem-1919	SELMODRAFT_89210	D8RAP2	SELMODRAFT_89210
94		iEKPD-Sem-1920	SELMODRAFT_93773	D8RH29	SELMODRAFT_93773
95		iEKPD-Sem-1362	SELMODRAFT_96432	D8RLX3	SELMODRAFT_96432