※ PP2C family introduction

    Metal-dependent protein phosphatases (PPM) include protein phosphatases which dependent on manganese/magnesium ions (Mn²⁺/Mg²⁺). PPM group contains a high conserved catalytic domain instead of catalytic subunit and different regulatory domains determining the substrate recognition and function diversity. Like PPP group, metal ions play an important role in dephosphorylation reaction (1). PP2C contains 19 members in human genome, including PP2C like phosphatases. What's more, PP2C is one of the largest type of protein phosphatases in plants with at least 76 members in Arabidopsis thaliana. PP2C family members are involved in varieties of cellular processes including cell cycle, splicing, cellular stress signaling and some members function as tumor suppressor (2).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837
2. Lammers, T. and Lavi, S. (2007) Role of type 2C protein phosphatases in growth regulation and in cellular stress signaling. Crit Rev Biochem Mol Biol, 42, 437-461. PMID: 18066953

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Soa-0353	ENSSARG00000000392.1
2		iEKPD-Soa-0354	ENSSARG00000000559.1
3		iEKPD-Soa-0359	ENSSARG00000001175.1
4		iEKPD-Soa-0363	ENSSARG00000001651.1
5		iEKPD-Soa-0369	ENSSARG00000002723.1
6		iEKPD-Soa-0377	ENSSARG00000004394.1
7		iEKPD-Soa-0381	ENSSARG00000004607.1
8		iEKPD-Soa-0396	ENSSARG00000006838.1
9		iEKPD-Soa-0420	ENSSARG00000009894.1
10		iEKPD-Soa-0428	ENSSARG00000010905.1
11		iEKPD-Soa-0430	ENSSARG00000011090.1
12		iEKPD-Soa-0431	ENSSARG00000011113.1
13		iEKPD-Soa-0434	ENSSARG00000011607.1
14		iEKPD-Soa-0440	ENSSARG00000011996.1
15		iEKPD-Soa-0454	ENSSARG00000014443.1