※ PP2C family introduction

    Metal-dependent protein phosphatases (PPM) include protein phosphatases which dependent on manganese/magnesium ions (Mn²⁺/Mg²⁺). PPM group contains a high conserved catalytic domain instead of catalytic subunit and different regulatory domains determining the substrate recognition and function diversity. Like PPP group, metal ions play an important role in dephosphorylation reaction (1). PP2C contains 19 members in human genome, including PP2C like phosphatases. What's more, PP2C is one of the largest type of protein phosphatases in plants with at least 76 members in Arabidopsis thaliana. PP2C family members are involved in varieties of cellular processes including cell cycle, splicing, cellular stress signaling and some members function as tumor suppressor (2).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837
2. Lammers, T. and Lavi, S. (2007) Role of type 2C protein phosphatases in growth regulation and in cellular stress signaling. Crit Rev Biochem Mol Biol, 42, 437-461. PMID: 18066953

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Spr-0121	sr11461	E6ZJK8	sr11461
2		iEKPD-Spr-0125	sr12461	E6ZU93	sr12461
3		iEKPD-Spr-0136	sr15206	E6ZPH8	sr15206
4		iEKPD-Spr-0138	sr15693	E6ZRB8	sr15693
5		iEKPD-Spr-0144	sr16426	E6ZUE1	sr16426
6		iEKPD-Spr-0127	sr13141	E6ZYX6	Uac1