※ PP2C family introduction

    Metal-dependent protein phosphatases (PPM) include protein phosphatases which dependent on manganese/magnesium ions (Mn²⁺/Mg²⁺). PPM group contains a high conserved catalytic domain instead of catalytic subunit and different regulatory domains determining the substrate recognition and function diversity. Like PPP group, metal ions play an important role in dephosphorylation reaction (1). PP2C contains 19 members in human genome, including PP2C like phosphatases. What's more, PP2C is one of the largest type of protein phosphatases in plants with at least 76 members in Arabidopsis thaliana. PP2C family members are involved in varieties of cellular processes including cell cycle, splicing, cellular stress signaling and some members function as tumor suppressor (2).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837
2. Lammers, T. and Lavi, S. (2007) Role of type 2C protein phosphatases in growth regulation and in cellular stress signaling. Crit Rev Biochem Mol Biol, 42, 437-461. PMID: 18066953

  Reviewed (0)  or Unreviewed (18) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sus-0595	ENSSSCG00000016339.3	A0A287AVD8	ILKAP
2		iEKPD-Sus-0640	ENSSSCG00000004896.3	F1SMW1	PHLPP1
3		iEKPD-Sus-0633	ENSSSCG00000002739.3	I3LHG3	PHLPP2
4		iEKPD-Sus-0608	ENSSSCG00000027327.2	I3LA86	PP2D1
5		iEKPD-Sus-0598	ENSSSCG00000005084.3	F1SSI1	PPM1A
6		iEKPD-Sus-0587	ENSSSCG00000008451.3	F1S5K0	PPM1B
7		iEKPD-Sus-0607	ENSSSCG00000026665.2	I3LH52	PPM1D
8		iEKPD-Sus-0533	ENSSSCG00000038932.1	I3LNY3	PPM1E
9		iEKPD-Sus-0596	ENSSSCG00000010079.3	F1RL04	PPM1F
10		iEKPD-Sus-0588	ENSSSCG00000027135.2	A0A287BJ42	PPM1G
11		iEKPD-Sus-0523	ENSSSCG00000036751.1	A0A287AK28	PPM1H
12		iEKPD-Sus-0589	ENSSSCG00000006774.3	F1SBQ0	PPM1J
13		iEKPD-Sus-0532	ENSSSCG00000038867.1	A0A287BED7	PPM1K
14		iEKPD-Sus-0599	ENSSSCG00000023434.2	I3LTE2	PPM1L
15		iEKPD-Sus-0603	ENSSSCG00000011434.3	A0A287A9W1	PPM1M
16		iEKPD-Sus-0527	ENSSSCG00000037001.1	A0A287BHY6	PPM1N
17		iEKPD-Sus-0601	ENSSSCG00000009825.3	F1RNM7	PPTC7
18		iEKPD-Sus-0611	ENSSSCG00000000087.4	K7GLB8	TAB1