※ PP2C family introduction

    Metal-dependent protein phosphatases (PPM) include protein phosphatases which dependent on manganese/magnesium ions (Mn²⁺/Mg²⁺). PPM group contains a high conserved catalytic domain instead of catalytic subunit and different regulatory domains determining the substrate recognition and function diversity. Like PPP group, metal ions play an important role in dephosphorylation reaction (1). PP2C contains 19 members in human genome, including PP2C like phosphatases. What's more, PP2C is one of the largest type of protein phosphatases in plants with at least 76 members in Arabidopsis thaliana. PP2C family members are involved in varieties of cellular processes including cell cycle, splicing, cellular stress signaling and some members function as tumor suppressor (2).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837
2. Lammers, T. and Lavi, S. (2007) Role of type 2C protein phosphatases in growth regulation and in cellular stress signaling. Crit Rev Biochem Mol Biol, 42, 437-461. PMID: 18066953

  Reviewed (0)  or Unreviewed (18) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Tag-0672	ENSTGUG00000008628.1	H0ZE85
2		iEKPD-Tag-0579	ENSTGUG00000016177.1	H1A0T9
3		iEKPD-Tag-0661	ENSTGUG00000016606.1	H1A1Y7
4		iEKPD-Tag-0670	ENSTGUG00000006550.1	H0Z839	ILKAP
5		iEKPD-Tag-0710	ENSTGUG00000002028.1	H0YUW9	PHLPP1
6		iEKPD-Tag-0711	ENSTGUG00000008329.1	H0ZDF3	PHLPP2
7		iEKPD-Tag-0669	ENSTGUG00000012997.1	H0ZRZ1	PPM1A
8		iEKPD-Tag-0665	ENSTGUG00000003793.1	H0Z025	PPM1B
9		iEKPD-Tag-0681	ENSTGUG00000007882.1	H0ZC19	PPM1D
10		iEKPD-Tag-0679	ENSTGUG00000007416.1	H0ZAN8	PPM1E
11		iEKPD-Tag-0659	ENSTGUG00000014753.1	H0ZWY3	PPM1G
12		iEKPD-Tag-0662	ENSTGUG00000006354.1	H0Z7H9	PPM1H
13		iEKPD-Tag-0667	ENSTGUG00000017530.1	H1A4J6	PPM1J
14		iEKPD-Tag-0657	ENSTGUG00000002504.1	H0YWA6	PPM1K
15		iEKPD-Tag-0666	ENSTGUG00000011154.1	H0ZLM2	PPM1L
16		iEKPD-Tag-0663	ENSTGUG00000006115.1	H0Z6U0	PPM1M
17		iEKPD-Tag-0571	ENSTGUG00000006400.1	H0Z7M1	PPTC7
18		iEKPD-Tag-0680	ENSTGUG00000010239.1	H0ZIZ7	TAB1