※ PP2C family introduction

    Metal-dependent protein phosphatases (PPM) include protein phosphatases which dependent on manganese/magnesium ions (Mn²⁺/Mg²⁺). PPM group contains a high conserved catalytic domain instead of catalytic subunit and different regulatory domains determining the substrate recognition and function diversity. Like PPP group, metal ions play an important role in dephosphorylation reaction (1). PP2C contains 19 members in human genome, including PP2C like phosphatases. What's more, PP2C is one of the largest type of protein phosphatases in plants with at least 76 members in Arabidopsis thaliana. PP2C family members are involved in varieties of cellular processes including cell cycle, splicing, cellular stress signaling and some members function as tumor suppressor (2).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837
2. Lammers, T. and Lavi, S. (2007) Role of type 2C protein phosphatases in growth regulation and in cellular stress signaling. Crit Rev Biochem Mol Biol, 42, 437-461. PMID: 18066953

  Reviewed (0)  or Unreviewed (6) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Trr-0142	TRIREDRAFT_124340	G0RMF5	acy1
2		iEKPD-Trr-0167	TRIREDRAFT_81164	G0RT93	ptc2
3		iEKPD-Trr-0156	TRIREDRAFT_58587	G0REI3	TRIREDRAFT_58587
4		iEKPD-Trr-0159	TRIREDRAFT_66702	G0RRA5	TRIREDRAFT_66702
5		iEKPD-Trr-0161	TRIREDRAFT_74030	G0R8D4	TRIREDRAFT_74030
6		iEKPD-Trr-0163	TRIREDRAFT_76083	G0RDJ3	TRIREDRAFT_76083