※ PP2C family introduction

    Metal-dependent protein phosphatases (PPM) include protein phosphatases which dependent on manganese/magnesium ions (Mn²⁺/Mg²⁺). PPM group contains a high conserved catalytic domain instead of catalytic subunit and different regulatory domains determining the substrate recognition and function diversity. Like PPP group, metal ions play an important role in dephosphorylation reaction (1). PP2C contains 19 members in human genome, including PP2C like phosphatases. What's more, PP2C is one of the largest type of protein phosphatases in plants with at least 76 members in Arabidopsis thaliana. PP2C family members are involved in varieties of cellular processes including cell cycle, splicing, cellular stress signaling and some members function as tumor suppressor (2).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837
2. Lammers, T. and Lavi, S. (2007) Role of type 2C protein phosphatases in growth regulation and in cellular stress signaling. Crit Rev Biochem Mol Biol, 42, 437-461. PMID: 18066953

  Reviewed (0)  or Unreviewed (6) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Trv-0195	TRIVIDRAFT_72651	G9MJ63	PTC2
2		iEKPD-Trv-0172	TRIVIDRAFT_181508	G9N0C0	TRIVIDRAFT_181508
3		iEKPD-Trv-0174	TRIVIDRAFT_189826	G9MMF3	TRIVIDRAFT_189826
4		iEKPD-Trv-0182	TRIVIDRAFT_211694	G9MFR5	TRIVIDRAFT_211694
5		iEKPD-Trv-0183	TRIVIDRAFT_214564	G9NA37	TRIVIDRAFT_214564
6		iEKPD-Trv-0186	TRIVIDRAFT_24738	G9N840	TRIVIDRAFT_24738