※ PP2C family introduction

    Metal-dependent protein phosphatases (PPM) include protein phosphatases which dependent on manganese/magnesium ions (Mn²⁺/Mg²⁺). PPM group contains a high conserved catalytic domain instead of catalytic subunit and different regulatory domains determining the substrate recognition and function diversity. Like PPP group, metal ions play an important role in dephosphorylation reaction (1). PP2C contains 19 members in human genome, including PP2C like phosphatases. What's more, PP2C is one of the largest type of protein phosphatases in plants with at least 76 members in Arabidopsis thaliana. PP2C family members are involved in varieties of cellular processes including cell cycle, splicing, cellular stress signaling and some members function as tumor suppressor (2).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837
2. Lammers, T. and Lavi, S. (2007) Role of type 2C protein phosphatases in growth regulation and in cellular stress signaling. Crit Rev Biochem Mol Biol, 42, 437-461. PMID: 18066953

  Reviewed (0)  or Unreviewed (6) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Tum-0115	GSTUM_00001578001	D5G5U2	GSTUM_00001578001
2		iEKPD-Tum-0119	GSTUM_00004009001	D5G494	GSTUM_00004009001
3		iEKPD-Tum-0128	GSTUM_00006808001	D5GFB2	GSTUM_00006808001
4		iEKPD-Tum-0132	GSTUM_00008785001	D5GJ21	GSTUM_00008785001
5		iEKPD-Tum-0135	GSTUM_00010137001	D5GLD1	GSTUM_00010137001
6		iEKPD-Tum-0137	GSTUM_00010370001	D5GLR5	GSTUM_00010370001