※ PP2C family introduction

    Metal-dependent protein phosphatases (PPM) include protein phosphatases which dependent on manganese/magnesium ions (Mn²⁺/Mg²⁺). PPM group contains a high conserved catalytic domain instead of catalytic subunit and different regulatory domains determining the substrate recognition and function diversity. Like PPP group, metal ions play an important role in dephosphorylation reaction (1). PP2C contains 19 members in human genome, including PP2C like phosphatases. What's more, PP2C is one of the largest type of protein phosphatases in plants with at least 76 members in Arabidopsis thaliana. PP2C family members are involved in varieties of cellular processes including cell cycle, splicing, cellular stress signaling and some members function as tumor suppressor (2).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837
2. Lammers, T. and Lavi, S. (2007) Role of type 2C protein phosphatases in growth regulation and in cellular stress signaling. Crit Rev Biochem Mol Biol, 42, 437-461. PMID: 18066953

  Reviewed (0)  or Unreviewed (16) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Tut-0473	ENSTTRG00000001186.1
2		iEKPD-Tut-0499	ENSTTRG00000004516.1
3		iEKPD-Tut-0523	ENSTTRG00000007596.1
4		iEKPD-Tut-0536	ENSTTRG00000008935.1
5		iEKPD-Tut-0542	ENSTTRG00000010013.1
6		iEKPD-Tut-0544	ENSTTRG00000010089.1
7		iEKPD-Tut-0555	ENSTTRG00000011481.1
8		iEKPD-Tut-0564	ENSTTRG00000012521.1
9		iEKPD-Tut-0578	ENSTTRG00000014578.1
10		iEKPD-Tut-0582	ENSTTRG00000015095.1
11		iEKPD-Tut-0585	ENSTTRG00000015238.1
12		iEKPD-Tut-0587	ENSTTRG00000015300.1
13		iEKPD-Tut-0599	ENSTTRG00000016801.1
14		iEKPD-Tut-0602	ENSTTRG00000017189.1
15		iEKPD-Tut-0607	ENSTTRG00000000154.1	H9LB18	PHLPP2
16		iEKPD-Tut-0606	ENSTTRG00000001256.1	H9LC41	PPM1B