※ PP2C family introduction

    Metal-dependent protein phosphatases (PPM) include protein phosphatases which dependent on manganese/magnesium ions (Mn²⁺/Mg²⁺). PPM group contains a high conserved catalytic domain instead of catalytic subunit and different regulatory domains determining the substrate recognition and function diversity. Like PPP group, metal ions play an important role in dephosphorylation reaction (1). PP2C contains 19 members in human genome, including PP2C like phosphatases. What's more, PP2C is one of the largest type of protein phosphatases in plants with at least 76 members in Arabidopsis thaliana. PP2C family members are involved in varieties of cellular processes including cell cycle, splicing, cellular stress signaling and some members function as tumor suppressor (2).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837
2. Lammers, T. and Lavi, S. (2007) Role of type 2C protein phosphatases in growth regulation and in cellular stress signaling. Crit Rev Biochem Mol Biol, 42, 437-461. PMID: 18066953

  Reviewed (1)  or Unreviewed (5) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Usm-0129	UMAG_05232	P49606	UAC1
2		iEKPD-Usm-0111	UMAG_00120	A0A0D1E6Z1	UMAG_00120
3		iEKPD-Usm-0117	UMAG_01391	A0A0D1E7N1	UMAG_01391
4		iEKPD-Usm-0126	UMAG_04320	A0A0D1DSC8	UMAG_04320
5		iEKPD-Usm-0127	UMAG_04819	A0A0D1DSB1	UMAG_04819
6		iEKPD-Usm-0140	UMAG_11184	A0A0D1DNT2	UMAG_11184