※ PP2C family introduction

    Metal-dependent protein phosphatases (PPM) include protein phosphatases which dependent on manganese/magnesium ions (Mn²⁺/Mg²⁺). PPM group contains a high conserved catalytic domain instead of catalytic subunit and different regulatory domains determining the substrate recognition and function diversity. Like PPP group, metal ions play an important role in dephosphorylation reaction (1). PP2C contains 19 members in human genome, including PP2C like phosphatases. What's more, PP2C is one of the largest type of protein phosphatases in plants with at least 76 members in Arabidopsis thaliana. PP2C family members are involved in varieties of cellular processes including cell cycle, splicing, cellular stress signaling and some members function as tumor suppressor (2).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837
2. Lammers, T. and Lavi, S. (2007) Role of type 2C protein phosphatases in growth regulation and in cellular stress signaling. Crit Rev Biochem Mol Biol, 42, 437-461. PMID: 18066953

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Ved-0156	VDAG_00016	G2WR33	VDAG_00016
2		iEKPD-Ved-0166	VDAG_03259	G2WZ17	VDAG_03259
3		iEKPD-Ved-0169	VDAG_04439	G2X2B5	VDAG_04439
4		iEKPD-Ved-0170	VDAG_04508	G2X2I4	VDAG_04508
5		iEKPD-Ved-0177	VDAG_07016	G2XAB3	VDAG_07016
6		iEKPD-Ved-0183	VDAG_08880	G2XG93	VDAG_08880
7		iEKPD-Ved-0184	VDAG_09695	G2XI45	VDAG_09695