※ PP2C family introduction

    Metal-dependent protein phosphatases (PPM) include protein phosphatases which dependent on manganese/magnesium ions (Mn²⁺/Mg²⁺). PPM group contains a high conserved catalytic domain instead of catalytic subunit and different regulatory domains determining the substrate recognition and function diversity. Like PPP group, metal ions play an important role in dephosphorylation reaction (1). PP2C contains 19 members in human genome, including PP2C like phosphatases. What's more, PP2C is one of the largest type of protein phosphatases in plants with at least 76 members in Arabidopsis thaliana. PP2C family members are involved in varieties of cellular processes including cell cycle, splicing, cellular stress signaling and some members function as tumor suppressor (2).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837
2. Lammers, T. and Lavi, S. (2007) Role of type 2C protein phosphatases in growth regulation and in cellular stress signaling. Crit Rev Biochem Mol Biol, 42, 437-461. PMID: 18066953

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Yal-0114	YALI0_B18759g	Q6CE40	YALI0_B18759g
2		iEKPD-Yal-0116	YALI0_B22616g	Q6CDN3	YALI0_B22616g
3		iEKPD-Yal-0118	YALI0_C03399g	Q6CD66	YALI0_C03399g
4		iEKPD-Yal-0123	YALI0_D22066g	Q6C875	YALI0_D22066g
5		iEKPD-Yal-0124	YALI0_E14795g	Q6C5V6	YALI0_E14795g
6		iEKPD-Yal-0128	YALI0_E27533g	Q6C4E0	YALI0_E27533g
7		iEKPD-Yal-0135	YALI0_F12617g	Q6C1X6	YALI0_F12617g