※ PP1 family introduction

    PP1 enzyme is composed of a catalytic subunit and a regulatory subunit(R subunit). The catalytic domain is conserved among all eukaryotes, and more than 100 regulatory subunits have been found to interact with C domain. Therefore, PP1 is a type of protein phosphatases of functional diversity which regulates a varieties of cellular processes through dephosphorylating different substrates. PP1 can promote the rational use of energy, especially when nutrients are abundant. PP1 plays a key role in the recovery from stress, however promotes apoptosis when cells are damaged beyond repair. In addition, PP1 can regulate the cell cycle (1).

Reference
1. Ceulemans, H. and Bollen, M. (2004) Functional diversity of protein phosphatase-1, a cellular economizer and reset button. Physiol Rev, 84, 1-39. PMID: 14715909

  Reviewed (0)  or Unreviewed (6) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sem-1416	SELMODRAFT_117581	D8SI14	SELMODRAFT_117581
2		iEKPD-Sem-1312	SELMODRAFT_144185	D8R577	SELMODRAFT_144185
3		iEKPD-Sem-1308	SELMODRAFT_184770	D8T291	SELMODRAFT_184770
4		iEKPD-Sem-1316	SELMODRAFT_228509	D8S3S9	SELMODRAFT_228509
5		iEKPD-Sem-1419	SELMODRAFT_230666	D8R3C8	SELMODRAFT_230666
6		iEKPD-Sem-1309	SELMODRAFT_235294	D8SVX0	SELMODRAFT_235294