Rattus norvegicus      PPP/PP2A


※ PP2A family introduction

    PP2A, a family of PPP, is ubiquitously expressed in all eukaryotes. Three subunits compose this phosphatase holoenzyme, among which, subunit A is a 60-65 kDa structural component, B is a regulatory subunit and C is a 36-38 kDa catalytic subunit. The substrate specificity, spatial and temporal functions of PP2A is determined by regulatory subunit B. PP2A is involved in a lot of cellular processes such as cell cycle regulation, cell morphology and development. In addition, PP2A plays a critical role in regulation of specific signal transduction cascades (1).

Reference
1. Basu, S. (2011) PP2A in the regulation of cell motility and invasion. Curr Protein Pept Sci, 12, 3-11. PMID: 21190527


There are 3 genes.  Reviewed (2 or Unreviewed (1

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Ran-0566
ENSRNOG00000005389.5
P63331
Ppp2ca
2
iEKPD-Ran-0571
ENSRNOG00000015182.6
P62716
Ppp2cb
3
iEKPD-Ran-0649
ENSRNOG00000001893.6
A0A0G2JYA4
LOC100362453