※ PPP_Unique family introduction

    Phosphoprotein phosphatase (PPP) is highly conserved among all eukaryotes. Seven phosphatases compose of PPP family in human genome, which are known as PP1, PP2A, PP2B (calcineurin), PP4, PP5, PP6 and PP7. PPP family phosphatases share a conserved catalytic domain ~280 amino acids and three signature motifs (-GDXHG-, -GDXVDRG- and -GNHE-) in its domain. The catalytic subunits of several members in PPP family always associate with a number of regulatory subunits, which regulate the substrate recognition and function. For PPP family members, metal ions play an important role during dephosphorylation reaction (1).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837

  Reviewed (1)  or Unreviewed (6) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Cae-0559	WBGene00018410	P34430	F44B9.9
2		iEKPD-Cae-0538	WBGene00017817	P91273	CELE_F26B1.5
3		iEKPD-Cae-0539	WBGene00018232	O01550	CELE_F40E3.5
4		iEKPD-Cae-0527	WBGene00018359	O44507	CELE_F42G8.8
5		iEKPD-Cae-0531	WBGene00009893	Q27500	CELE_F49E11.7
6		iEKPD-Cae-0545	WBGene00010992	Q09598	CELE_R03D7.8
7		iEKPD-Cae-g037	WBGene00044114	Q58AA2	srxa-11