Ciona intestinalis      PPP/PPP_Unique


※ PPP_Unique family introduction

    Phosphoprotein phosphatase (PPP) is highly conserved among all eukaryotes. Seven phosphatases compose of PPP family in human genome, which are known as PP1, PP2A, PP2B (calcineurin), PP4, PP5, PP6 and PP7. PPP family phosphatases share a conserved catalytic domain ~280 amino acids and three signature motifs (-GDXHG-, -GDXVDRG- and -GNHE-) in its domain. The catalytic subunits of several members in PPP family always associate with a number of regulatory subunits, which regulate the substrate recognition and function. For PPP family members, metal ions play an important role during dephosphorylation reaction (1).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837


There are 4 genes.  Reviewed (0 or Unreviewed (4

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Cii-0342
ENSCING00000005224.3
F6XVF3
2
iEKPD-Cii-0296
ENSCING00000025048.1
H2XPH8
3
iEKPD-Cii-g009
ENSCING00000017704.2
F6WBQ8
4
iEKPD-Cii-0292
ENSCING00000018858.1
H2XQU6
LOC100187334