※ PPP_Unique family introduction

    Phosphoprotein phosphatase (PPP) is highly conserved among all eukaryotes. Seven phosphatases compose of PPP family in human genome, which are known as PP1, PP2A, PP2B (calcineurin), PP4, PP5, PP6 and PP7. PPP family phosphatases share a conserved catalytic domain ~280 amino acids and three signature motifs (-GDXHG-, -GDXVDRG- and -GNHE-) in its domain. The catalytic subunits of several members in PPP family always associate with a number of regulatory subunits, which regulate the substrate recognition and function. For PPP family members, metal ions play an important role during dephosphorylation reaction (1).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sem-1173	SELMODRAFT_130493	D8T2G9	SELMODRAFT_130493
2		iEKPD-Sem-1174	SELMODRAFT_131016	D8T3F7	SELMODRAFT_131016
3		iEKPD-Sem-1422	SELMODRAFT_159648	D8SZC7	SELMODRAFT_159648
4		iEKPD-Sem-g028	SELMODRAFT_6160	D8RFN5	SELMODRAFT_26991
5		iEKPD-Sem-g011	SELMODRAFT_410270	D8RE76	SELMODRAFT_410270
6		iEKPD-Sem-g048	SELMODRAFT_416854	D8SBA4	SELMODRAFT_420209
7		iEKPD-Sem-g007	SELMODRAFT_425664	D8STV4	SELMODRAFT_425664
8		iEKPD-Sem-1421	SELMODRAFT_55601	D8RUI7	SELMODRAFT_55601