Anolis carolinensis      RGC/RGC


※ RGC family introduction

    RGCs are Receptor Guanylate Cyclases that have an unusual structure: they are single-pass transmembrane receptors that have an active guanylate cyclase domain and a catalytically inactive kinase domain on the intracellular side. The guanylate cyclase domain makes the second messenger cGMP, and the kinase domain may have a regulatory role and may bind ATP (1,2).

Reference
1. Manning, G., Whyte, D.B., Martinez, R., Hunter, T. and Sudarsanam, S. (2002) The protein kinase complement of the human genome. Science, 298, 1912-1934. PMID: 12471243
2. Wikinome annotation:    Kinase Group RGC


There are 7 genes.  Reviewed (0 or Unreviewed (7

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Anc-0042
ENSACAG00000001580.3
H9G5F9
2
iEKPD-Anc-0248
ENSACAG00000010233.3
H9GGB6
GUCY2C
3
iEKPD-Anc-0127
ENSACAG00000005489.3
H9GAD2
GUCY2D
4
iEKPD-Anc-0265
ENSACAG00000011233.2
H9GHE3
LOC100556473
5
iEKPD-Anc-0240
ENSACAG00000009932.3
H9GFU9
LOC100564400
6
iEKPD-Anc-g012
ENSACAG00000013114.3
H9GJN8
LOC103282089
7
iEKPD-Anc-0349
ENSACAG00000014358.3
H9GL44
NPR2