※ RGC family introduction

    RGCs are Receptor Guanylate Cyclases that have an unusual structure: they are single-pass transmembrane receptors that have an active guanylate cyclase domain and a catalytically inactive kinase domain on the intracellular side. The guanylate cyclase domain makes the second messenger cGMP, and the kinase domain may have a regulatory role and may bind ATP (1,2).

Reference
1. Manning, G., Whyte, D.B., Martinez, R., Hunter, T. and Sudarsanam, S. (2002) The protein kinase complement of the human genome. Science, 298, 1912-1934. PMID: 12471243
2. Wikinome annotation:    Kinase Group RGC

  Reviewed (0)  or Unreviewed (5) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Caj-0453	ENSCJAG00000021614.3	F7ILJ2	GUCY2C
2		iEKPD-Caj-0309	ENSCJAG00000014688.2	F7EAY0	GUCY2D
3		iEKPD-Caj-0162	ENSCJAG00000007378.2	F6VDS0	GUCY2F
4		iEKPD-Caj-0215	ENSCJAG00000010210.1	F7HB05	NPR1
5		iEKPD-Caj-0210	ENSCJAG00000009970.2	F7G8K7	NPR2