※ RGC family introduction

    RGCs are Receptor Guanylate Cyclases that have an unusual structure: they are single-pass transmembrane receptors that have an active guanylate cyclase domain and a catalytically inactive kinase domain on the intracellular side. The guanylate cyclase domain makes the second messenger cGMP, and the kinase domain may have a regulatory role and may bind ATP (1,2).

Reference
1. Manning, G., Whyte, D.B., Martinez, R., Hunter, T. and Sudarsanam, S. (2002) The protein kinase complement of the human genome. Science, 298, 1912-1934. PMID: 12471243
2. Wikinome annotation:    Kinase Group RGC

  Reviewed (0)  or Unreviewed (4) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Cas-0164	ENSTSYG00000007144.2	A0A1U7UMX8	GUCY2C
2		iEKPD-Cas-0191	ENSTSYG00000008254.2	A0A1U7U3S6	GUCY2D
3		iEKPD-Cas-0270	ENSTSYG00000011980.2	A0A1U7UZ17	GUCY2F
4		iEKPD-Cas-0070	ENSTSYG00000002662.2	A0A1U7U5Y4	NPR2