Cavia porcellus      RGC/RGC


※ RGC family introduction

    RGCs are Receptor Guanylate Cyclases that have an unusual structure: they are single-pass transmembrane receptors that have an active guanylate cyclase domain and a catalytically inactive kinase domain on the intracellular side. The guanylate cyclase domain makes the second messenger cGMP, and the kinase domain may have a regulatory role and may bind ATP (1,2).

Reference
1. Manning, G., Whyte, D.B., Martinez, R., Hunter, T. and Sudarsanam, S. (2002) The protein kinase complement of the human genome. Science, 298, 1912-1934. PMID: 12471243
2. Wikinome annotation:    Kinase Group RGC


There are 5 genes.  Reviewed (0 or Unreviewed (5

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Cap-0197
ENSCPOG00000008513.4
H0VCJ2
GUCY2C
2
iEKPD-Cap-0047
ENSCPOG00000001487.4
H0UWB3
GUCY2D
3
iEKPD-Cap-0149
ENSCPOG00000006348.4
H0V7L0
GUCY2F
4
iEKPD-Cap-0404
ENSCPOG00000025084.2
H0W391
NPR1
5
iEKPD-Cap-0013
ENSCPOG00000000414.4
H0UTW0
NPR2