Danio rerio      RGC/RGC


※ RGC family introduction

    RGCs are Receptor Guanylate Cyclases that have an unusual structure: they are single-pass transmembrane receptors that have an active guanylate cyclase domain and a catalytically inactive kinase domain on the intracellular side. The guanylate cyclase domain makes the second messenger cGMP, and the kinase domain may have a regulatory role and may bind ATP (1,2).

Reference
1. Manning, G., Whyte, D.B., Martinez, R., Hunter, T. and Sudarsanam, S. (2002) The protein kinase complement of the human genome. Science, 298, 1912-1934. PMID: 12471243
2. Wikinome annotation:    Kinase Group RGC


There are 10 genes.  Reviewed (0 or Unreviewed (10

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Dar-0138
ENSDARG00000018329.10
E7F111
gc2
2
iEKPD-Dar-0102
ENSDARG00000014320.10
A0A0R4IA00
gucy2c
3
iEKPD-Dar-0188
ENSDARG00000026820.10
A2BFQ0
gucy2d
4
iEKPD-Dar-0180
ENSDARG00000025504.10
B3DHF2
gucy2f
5
iEKPD-Dar-0541
ENSDARG00000076776.2
E7FDF3
gucy2g
6
iEKPD-Dar-0222
ENSDARG00000031751.9
Q1LX84
npr1a
7
iEKPD-Dar-0145
ENSDARG00000018750.9
E7F3T9
npr1b
8
iEKPD-Dar-0954
ENSDARG00000104393.1
A0A0G2KGK2
npr2
9
iEKPD-Dar-0351
ENSDARG00000056045.7
U3JAG6
si:ch73-139e5.4
10
iEKPD-Dar-0412
ENSDARG00000060264.7
F1R1B5
si:dkey-37g12.1