Latimeria chalumnae      RGC/RGC


※ RGC family introduction

    RGCs are Receptor Guanylate Cyclases that have an unusual structure: they are single-pass transmembrane receptors that have an active guanylate cyclase domain and a catalytically inactive kinase domain on the intracellular side. The guanylate cyclase domain makes the second messenger cGMP, and the kinase domain may have a regulatory role and may bind ATP (1,2).

Reference
1. Manning, G., Whyte, D.B., Martinez, R., Hunter, T. and Sudarsanam, S. (2002) The protein kinase complement of the human genome. Science, 298, 1912-1934. PMID: 12471243
2. Wikinome annotation:    Kinase Group RGC


There are 8 genes.  Reviewed (0 or Unreviewed (8

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Lac-0003
ENSLACG00000000158.1
H2ZS04
2
iEKPD-Lac-0190
ENSLACG00000007436.1
H3AFH5
3
iEKPD-Lac-0320
ENSLACG00000012235.1
H3AW78
GUCY2C
4
iEKPD-Lac-0275
ENSLACG00000010494.1
H3AQK2
GUCY2D
5
iEKPD-Lac-0131
ENSLACG00000004776.1
H3A6V1
GUCY2F
6
iEKPD-Lac-0264
ENSLACG00000010090.1
H3APA0
LOC102351946
7
iEKPD-Lac-0401
ENSLACG00000015737.1
H3B7J3
LOC102366518
8
iEKPD-Lac-0156
ENSLACG00000005999.1
H3AAU2
NPR1