Mus musculus      RGC/RGC


※ RGC family introduction

    RGCs are Receptor Guanylate Cyclases that have an unusual structure: they are single-pass transmembrane receptors that have an active guanylate cyclase domain and a catalytically inactive kinase domain on the intracellular side. The guanylate cyclase domain makes the second messenger cGMP, and the kinase domain may have a regulatory role and may bind ATP (1,2).

Reference
1. Manning, G., Whyte, D.B., Martinez, R., Hunter, T. and Sudarsanam, S. (2002) The protein kinase complement of the human genome. Science, 298, 1912-1934. PMID: 12471243
2. Wikinome annotation:    Kinase Group RGC


There are 7 genes.  Reviewed (6 or Unreviewed (1

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Mum-0368
ENSMUSG00000042638.14
Q3UWA6
Gucy2c; Guc2c
2
iEKPD-Mum-0100
ENSMUSG00000020890.11
P52785
Gucy2e; Guc2e
3
iEKPD-Mum-0364
ENSMUSG00000042282.4
Q5SDA5
Gucy2f
4
iEKPD-Mum-0410
ENSMUSG00000055523.6
Q6TL19
Gucy2g
5
iEKPD-Mum-0211
ENSMUSG00000027931.12
P18293
Npr1; Npra
6
iEKPD-Mum-0219
ENSMUSG00000028469.15
Q6VVW5
Npr2
7
iEKPD-Mum-0454
ENSMUSG00000074003.4
A0A0U1RPR8
Gucy2d