Otolemur garnettii      RGC/RGC


※ RGC family introduction

    RGCs are Receptor Guanylate Cyclases that have an unusual structure: they are single-pass transmembrane receptors that have an active guanylate cyclase domain and a catalytically inactive kinase domain on the intracellular side. The guanylate cyclase domain makes the second messenger cGMP, and the kinase domain may have a regulatory role and may bind ATP (1,2).

Reference
1. Manning, G., Whyte, D.B., Martinez, R., Hunter, T. and Sudarsanam, S. (2002) The protein kinase complement of the human genome. Science, 298, 1912-1934. PMID: 12471243
2. Wikinome annotation:    Kinase Group RGC


There are 7 genes.  Reviewed (0 or Unreviewed (7

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Otg-0417
ENSOGAG00000026738.1
H0XL13
2
iEKPD-Otg-0337
ENSOGAG00000014186.2
H0XAQ1
GUCY2C
3
iEKPD-Otg-0042
ENSOGAG00000001946.2
H0WJQ1
GUCY2D
4
iEKPD-Otg-0273
ENSOGAG00000011569.2
H0X530
GUCY2F
5
iEKPD-Otg-0441
ENSOGAG00000029463.1
H0Y0M9
LOC100945296
6
iEKPD-Otg-0447
ENSOGAG00000030073.1
H0XRQ4
NPR1
7
iEKPD-Otg-0278
ENSOGAG00000011822.2
H0X5L2
NPR2