Pan troglodytes      RGC/RGC


※ RGC family introduction

    RGCs are Receptor Guanylate Cyclases that have an unusual structure: they are single-pass transmembrane receptors that have an active guanylate cyclase domain and a catalytically inactive kinase domain on the intracellular side. The guanylate cyclase domain makes the second messenger cGMP, and the kinase domain may have a regulatory role and may bind ATP (1,2).

Reference
1. Manning, G., Whyte, D.B., Martinez, R., Hunter, T. and Sudarsanam, S. (2002) The protein kinase complement of the human genome. Science, 298, 1912-1934. PMID: 12471243
2. Wikinome annotation:    Kinase Group RGC


There are 5 genes.  Reviewed (0 or Unreviewed (5

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Pat-0076
ENSPTRG00000004721.4
H2Q5I3
GUCY2C
2
iEKPD-Pat-0157
ENSPTRG00000008720.6
H2QC65
GUCY2D
3
iEKPD-Pat-0414
ENSPTRG00000022174.4
H2QZ00
GUCY2F
4
iEKPD-Pat-0021
ENSPTRG00000001359.5
H2Q039
NPR1
5
iEKPD-Pat-0395
ENSPTRG00000020921.7
H2QX89
NPR2