Rattus norvegicus      RGC/RGC


※ RGC family introduction

    RGCs are Receptor Guanylate Cyclases that have an unusual structure: they are single-pass transmembrane receptors that have an active guanylate cyclase domain and a catalytically inactive kinase domain on the intracellular side. The guanylate cyclase domain makes the second messenger cGMP, and the kinase domain may have a regulatory role and may bind ATP (1,2).

Reference
1. Manning, G., Whyte, D.B., Martinez, R., Hunter, T. and Sudarsanam, S. (2002) The protein kinase complement of the human genome. Science, 298, 1912-1934. PMID: 12471243
2. Wikinome annotation:    Kinase Group RGC


There are 7 genes.  Reviewed (6 or Unreviewed (1

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Ran-0149
ENSRNOG00000009031.5
P23897
Gucy2c
2
iEKPD-Ran-0235
ENSRNOG00000015058.6
P51839
Gucy2d
3
iEKPD-Ran-0307
ENSRNOG00000019086.4
P51842
Gucy2f
4
iEKPD-Ran-0246
ENSRNOG00000015724.5
P55205
Gucy2g
5
iEKPD-Ran-0230
ENSRNOG00000014684.3
P18910
Npr1
6
iEKPD-Ran-0248
ENSRNOG00000015991.7
P16067
Npr2
7
iEKPD-Ran-0131
ENSRNOG00000007931.4
V9GZ79
Gucy2d