Cryptococcus neoformans      STE/STE11


※ STE11 family introduction

    STE11 family kinases are mitogen-activated protein kinase kinase kinase. Eight kinases compose this family and act as an essential component of the MAP kinase signal transduction pathway. STE11 family contains some subfamilys. MAP3K1/2/3/5/6 appears to diverged from SC:STE11, SCBCK1, SP:MHK1 and SP:BR2. SC:STE11 plays an important role in mating and filamentation-invasion pathways, BCK1 is responsible for nutrient sensing and growth, MHK1 is involved in cell-wall integrity, BYR2 participate innutrient sensing and pheromone signaling. MAP3K1/2/3/5/6 also act as key molecules in the JNK pathway, inflammation and cell apoptosis (1).

Reference
1. Kinase Pathway Database:STE11 Family


There are 5 genes.  Reviewed (0 or Unreviewed (5

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Crn-0013
CNA07600
Q5KN62
CNA07600
2
iEKPD-Crn-0039
CND05760
Q5KHP6
CND05760
3
iEKPD-Crn-0041
CND06250
Q5KHJ6
CND06250
4
iEKPD-Crn-0086
CNJ01850
Q5KAF9
CNJ01850
5
iEKPD-Crn-0098
CNL05560
Q5K8I5
CNL05560